Active chemical substance: IGF-1 long R3.
The hypothesis that the insulin-like growth factor in its biological effect serves as an agent of the well-known somatotropichormone was proposed in 1957 by two scientists: Salmon and Daughaday. During the following years after identification and establishment of the chemical structure of this substance, it turned out that there are in fact two compounds: insulin-like growth factor 1 and 2 (IGF-1 and IGF-2). Scientists found out that IGF-1 and IGF-2 molecules are simple polypeptide chains containing respectively 70 and 67 amino acid residues. It also turned out that the structures of the said substances have much more in common with pro-insulin, the structural predecessor of insulin. The first factor, i.e. IGF-1, is the most important one for us from these two factors, so we will examine only IGF-1 below.
Muscle growth mechanism and IGF-1 role in this process
The material below is far from fully covering the topic, let alone being the ultimate truth. However, the above hypothesis is currently closest to reality and explains the key role of the insulin-like growth factor in building new muscle fibers. Ability of muscle fibers to grow by responding to external irritants, primarily to physical activity, is unique. And this ability largely depends on the so-called satellite cells. Satellite cells are a kind of precursors of muscle cells (fibers), the material necessary to build muscles. Satellite cells always surround muscle fibers (by the way, their quantity suddenly increases as a result of consuming high doses of androgens such as testosterone, trenbolone, or nandrolone), but they are in a kind of a sleeping condition. Transition from sleep to a wakeful state is carried out under the effect of the growth factor, for example, IGF-1. Impacted by IGF-1, satellite cells begin to intensely divide and, moreover, start to genetically modify: the nucleus of these cells becomes identical to the nucleus of muscle fibers. These new cells with a modified nucleus are extremely necessary to generate new muscle fibers. Therefore, the increasing IGF-1 level leads to generation of new muscle fibers, i.e. hyperplasia of muscles. In this sense, the insulin-like growth factor is highly important for us. However, the IGF-1 role in muscle fiber growth is not limited to the above only. Detailed description of another mechanism of the insulin-like growth factor’s impact on generation of new muscle fibers cannot be fit into this article; all we will say is that IGF-1 helps increase the concentration of calcium ions inside a cell. As a result, such increase is a signal to muscle fiber pushing it into hypertrophy of IGF-1 long-R3.
Why is the hormone growth necessary?
Most of us must have heard the term “growth hormones”. We are not going to repeat what has already been said about it; instead, we are going to briefly describe this hormone action mechanism, which is quite important for us as it will be shown later. There are two theories explaining the GH action mechanism: the direct action theory and the somatomedin theory (indirect action). According to the first theory, free somatotropin molecules (i.e. unbound ones) can directly affect cells by binding with receptors of the growth hormone on their surface. This theory is partly proved through experiments on mice, during which the growth hormone (very important!) was injected directly to the spot of the anticipated effect. The second theory states that the growth hormone affects the body through its intermediate substance. It was proved that this substance is the insulin-like growth factor. Which theory is the true one? The answer is paradoxical: both are true. IGF-1 is synthesized in the liver and is released into the general blood flow under the direct effect of the growth hormone. Blood takes this factor to various tissues and bodies having an anabolic effect on them. However, apart from the liver, IGF-1 can be also synthesized in the tissue and even in the cell, where it will act later. Unlike the somatotropin, which is an endocrine hormone, IGF-1 can have both the paracrine and even autocrine effect. The insulin-like growth factor inside muscle fibers is synthesized under the effect of external actions: one of the experiments showed that the weight session results in increased generation of IGF-1 inside muscle fibers: by 34% in case of the low intensity of the session and by 30% in case of the high one. It can be synthesized under the effect of high doses of androgens as well. And here is the most interesting aspect: IGF-1 generated in the liver is genetically slightly different from IGF-1 synthesized inside muscle fibers. The latter can initiate growth of the bone tissue, bands, and internal parts of the body only. The former triggers hypertrophy and hyperplasia of muscles. Systeminjection (i.e. injection in the general blood flow) of the insulin-like growth factor, just as the increased IGF-1synthesis in the liver, provoked by the system injection of the exogeneticsomatotropin do not practically lead to growth of the volume and quantity of muscle fibers. This situation can be partially corrected by local injection of the growth hormone, in which case it will enhance action of IGF-1 to some extent both generated inside the cell under the effect of external factors and locally injected from the outside. One would say that IGF-1 does not need the growth factor after all because the most important is to provoke the increased synthesis of the insulin-like growth factor inside muscle fibers, and the weight session (in particular, lowly intensive one) or high doses of androgens will be enough for that. And if we combine the setwoprocesses… .But things are not so simple. The insulin-like growth factor needs the somatotropin to a large extent. And here is the reason for that. IGF-1 can be found in two states in the body: bound and non-bound. It is mainly bound by protein marked asIGFBP-3. In the unbound state, IGF-1 is active, but it lives for just several minutes. It is inactive in the unbound state, but its life considerably extends to several hours. The growth hormone increases the IGFBP-3 synthesis and extends the insulin-like growth factor’s life in this way. The first experiments involving the synthetic IGF-1, even when it was locally injected, revealed no conspicuous muscle growth. It was because of a very short period of semi-life of the insulin-like growth factor: the preparation had no time to make an expressed effect. By the way, this experiment revealed that the weight session, regardless of its intensity, fails to lead to any conspicuous IGFBP-3increase in blood. In other words, during such a session, the insulin-like growth factor inside the cell has a very low period of semi-life and simply has no time to make any considerable effect on growth of muscle fibers. It means that we cannot do without the growth hormone as it was the key component ensuring the fruitful functioning of IGF-1 anyway. But this was true prior to creation of the preparation called IGTROPIN.
How is IGTROPIN different?
One of the main distinctions of IGTROPIN among similar preparations is that it combines IGF-1 and the binding protein, which permits to considerably extend semi-life of the preparation and, therefore, increase its efficiency. At the same time, use of the growth hormone in combination with IGTROPIN becomes irrelevant. At present, IGTROPIN can be considered a unique preparation as nothing that could match it had been produced before. Chinese pharmacists called the effective substance of the newly created preparation IGF-1 Long R3, emphasizing combination of the insulin-like growth factor and the binding protein.
Practical recommendations for using the preparation
There is no much information in the world on how athletes use IGF-1 long R3; therefore, it is currently difficult to give any recommendations on application of the above preparation. Information on use of IGTROPIN has just started to be collected. We can be absolutely confident that the highest effect is achieved through local injection of IGF-1 long R3, i.e. its injection into the muscle growth of which is to be initiated. It should be noted that local application of IGF-1 long R3 is more efficient that injection of synthol. Combination of testosterone, insulin, and triiodothyronine, apart from somatotropin and IGF-1 long R3, has become particularly popular with professional bodybuilders. Dorian Yets was one of the first athletes to use such combination in practice. It should be emphasized that the above combination was useful for the then five-time Mister Olympia. However, in case of using IGTROPIN, its combination with the growth hormone is unlikely to be effective, as was mentioned above: the preparation’s semi-life is long enough. Use of testosterone, insulin, and triiodothyronine can be reasonable: all of them stimulate generation of the insulin-like growth factor in the liver and, in combination with locally injected IGF-1 long R3, this ensures a bomb-like effect indeed. Testosterone, in particular, increases the number of satellite cells, which constitute the material necessary to generate new muscle fibers. So athletes have to use it. We emphasize again that experience in using IGF-1 long R3 only starts to be accumulate; therefore, we are not going to give any specific recommendations on how to use the preparation, the time of use and doses of IGTROPIN, or any related preparations. As regards the weight session, it is necessary to focus on exercises leading to expressed muscle burning: combined sets, supersets, trisets, drop-sets, forced reps. Good results can be achieved by periodically turning to pumping. Recent research show that the level of IGF-1 long R3 can be considerably increased in the body as a result of flexibility exercises, in particular those that are made after using large weights. It is also necessary to keep in mind the negative effect of anti-estrogen such as tamoksifen on generation of the insulin-like growth factor and try to avoid its consumption; it is positive that our market offers a lot of such anti-estrogen preparations. Anyway, we can be confident that the sports pharmacology has experienced real breakthrough due to emergence of the preparation that can considerably help athletes build muscles. In this sense, it is extremely important.