Growth Hormone Releasing Peptides or Peptides stimulating endogenous Growth Hormone secretion
Growth Hormone Releasing Peptides (GHRP-2, GHRP-6 and Hexarelin) are a small family of peptides acting at the pituitary and the hypothalamus to release Growth hormone (GH). These peptides were discovered 20 years ago and in clinical researches proved to be able to stimulate pituitary to produce endogenous Growth hormone.
GHRP-2, GHRP-6 and Hexarelin are replaceable drugs and have similar mechanism of action.
Hexarelin is considered to be the strongest peptide stimulating GH secretion. With its use, the increase in cortisol and prolactin levels is also high enough. GHRP-2 is less strong than Hexarelin, but the increase in cortisol and prolactin levels is less too. GHRP-6 is less strong than GHRP-2, but when used in dosage up to 100mcg, it has no influence on the levels of cortisol and prolactin, and in dosage more than 100mcg, the increase in cortisol and prolactin levels is modest.
Another drug stimulating endogenous GH secretion is long-acting CJC-1295 (Long-acting Growth Hormone Releasing Hormone Analog).
Common dosage regimen of Peptides:
Cycle: 16 months. The dosage is prescribed individually and injected 1-6 times a day starting with 25-50mcg and gradually increasing it with the step of 25-50mcg to achieve minimal side effects. Then, there should be return to the starting dose. The injections are usually made subcutaneously in an abdominal area 30 minutes before or in 1-1.5 after meal. The time between injections should be 3-4 hours (in order the body has the time to produce GH for further release).
Growth Hormone Releasing Peptide-6 (GHRP-6)
Growth Hormone Releasing Peptide-6 (GHRP-6) is a peptide made up of 28 amino acids, which stimulates secretion of endogenous GH and inhibits myostatin action. One of the main effects of GHRP-6 is promotion of appetite (due to stimulation of ghrelin secretion) and metabolism.
When GHRP-6 is injected, the level of basal GH is increased by 4 times, and the level of IGF-1 remains increased within 7 days after injection. As far as GHRP-6 stimulates GH secretion, it has the same effects as GH itself (increase of muscle mass, improving of skin, joints and immunity) and the same possible side effects of GH. GHRP-6 can be administered not only independently, but also in combinations with anabolic steroids. GHRP-6 is recommended to administer, if there is no possibility to administer synthetic GH or there is a need to stimulate endogenous GH secretion inhibited with the use of synthetic GH. GHRP-6 is often co-administered with Hexarelin. GHRP-6 is also recommended to administer at the bulk stage of a cycle.
Medicinally, GHRP-6 can be used in complex therapy for treating eating disorders and cachexia.