Growth Hormone Releasing Peptides or Peptides stimulating endogenous Growth Hormone secretion
Growth Hormone Releasing Peptides (GHRP-2, GHRP-6 and Hexarelin) are a small family of peptides acting at the pituitary and the hypothalamus to release Growth hormone (GH). These peptides were discovered 20 years ago and in clinical researches proved to be able to stimulate pituitary to produce endogenous Growth hormone.
GHRP-2, GHRP-6 and Hexarelin are replaceable drugs and have similar mechanism of action.
Hexarelin is considered to be the strongest peptide stimulating GH secretion. With its use, the increase in cortisol and prolactin levels is also high enough. GHRP-2 is less strong than Hexarelin, but the increase in cortisol and prolactin levels is less too. GHRP-6 is less strong than GHRP-2, but when used in dosage up to 100mcg, it has no influence on the levels of cortisol and prolactin, and in dosage more than 100mcg, the increase in cortisol and prolactin levels is modest.
Another drug stimulating endogenous GH secretion is long-acting CJC-1295 (Long-acting Growth Hormone Releasing Hormone Analog).
Common dosage regimen of Peptides:
Cycle: 16 months. The dosage is prescribed individually and injected 1-6 times a day starting with 25-50mcg and gradually increasing it with the step of 25-50mcg to achieve minimal side effects. Then, there should be return to the starting dose. The injections are usually made subcutaneously in an abdominal area 30 minutes before or in 1-1.5 after meal. The time between injections should be 3-4 hours (in order the body has the time to produce GH for further release).
Growth Hormone Releasing Peptide-2 (GHRP-2)
Growth Hormone Releasing Peptide-2 (GHRP-2) is a peptide made up of just six amino acids, which stimulates secretion of endogenous GH. In researches, GHRP-2 showed ability to stimulate the pituitary to increase secretion of GH by 7-15 times, to stimulate ghrelin receptors and in such a way to promote appetite.
According to the results of clinical trial, which were published in The Endocrinology and Metabolism Magazine in 1997, GHRP-2 increases GH secretion both in adults and children, and even in elders.
The main effects of GHRP-2 are GH secretion stimulation, appetite promotion, fat mass decrease and muscle mass increase, lowering of cholesterol level, skin and bones state improving, defense of the liver and anti-inflammatory action.
The researches confirmed high safety of GHRP-2 and almost no side effects, if GHRP-2 is administered within the recommended dose range. GHRP-2 has been clinically trialed for 30 years. Thus, delayed side effects can be excluded.